Bayer's PRINCE Platform: Agentic RAG and Text-to-SQL for Drug Safety Data

Bayer and Thoughtworks built PRINCE, a production agentic system combining RAG and Text-to-SQL to query decades of preclinical safety study reports and draft regulatory documents. The paper details context engineering — how information is shaped between specialized agents — and harness engineering covering orchestration, recovery, and observability for reliability in a compliance-sensitive environment.